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Each year, one-third of the total food for human consumption is either lost or wasted even as millions worldwide experience food insecurity. Similarly, over 25 percent of vaccines are wasted each year while millions die from vaccine-preventable illnesses Sustainable cold chain infrastructure can significantly reduce post-harvest food loss and vaccine wastage and deliver social and climate benefits. However, acknowledging the need for cold storage alone does not ensure food security or access to vaccines, and must be supported by policies and resources, including technologies. Cooperation among G20 countries on cold chains can help coordinate the policies and resources necessary to advance food security, public health, and climate change mitigation.